Causes of peripheral neuropathy?

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Some of the chemotherapy and other drugs used to treat cancer can damage peripheral nerves. When this happens it is called chemotherapy-induced peripheral neuropathy (CIPN). This can be a disabling side effect of cancer treatment.

CIPN can cause severe pain and can affect your ability to do things like walk, write, button your shirt, or pick up coins. CIPN can last for weeks, months, or even years after treatment is done. If it gets very bad, it can cause more serious problems like changes in your heart rate and blood pressure, dangerous falls, trouble breathing, paralysis, or organ failure.

Peripheral neuropathy can be caused by other things besides chemotherapy; such as:

  • Other cancer treatments, like surgery or radiation
  • Tumors pressing on nerves
  • Infections that affect the nerves
  • Spinal cord injuries
  • Diabetes
  • Alcohol abuse
  • Shingles
  • Low vitamin B levels
  • Some autoimmune disorders
  • HIV (human immunodeficiency virus) infection
  • Poor circulation (peripheral vascular disease)

It’s very important to know what’s causing peripheral neuropathy so that the right treatment can be given. Nutronco developed PowerNerve, a nutritional supplement based on clinical studies that have shown significant results that may help prevent the onset during chemotherapy treatment or to address the nerve pain from other symptoms.

What drugs are most likely to cause chemotherapy-induced peripheral neuropathy?

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Chemotherapy induced neuropathy

Certain chemo drugs are more likely to cause CIPN. Some of the more common ones include:

You are just recovering from the shock from being diagnosed for cancer. Your physician tells you the good news that with today’s modern treatment that your survivability and chance to enjoy a long life are very high. You endure the challenges of treatment and are cancer free, but now have chemotherapy induced peripheral neuropathy from certain chemo drugs. Can you do anything to prevent or reduce the impact of CIPN?

  • Platinum drugs like cisplatin, carboplatin, and oxaliplatin
  • Taxanes, including paclitaxel (Taxol®), docetaxel (Taxotere®), and cabazitaxel (Jevtana®)
  • Plant alkaloids, such as vinblastine, vincristine, vinorelbine, and etoposide (VP-16)
  • Immunomodulating drugs (IMiDs), like thalidomide (Thalomid®), lenalidomide (Revlimid®), and pomalidomide (Pomalyst®)
  • Proteasome inhibitors, such as bortezomib (Velcade®), carfilzomib (Kyprolis®), and ixazomib (Ninlaro)

If you are motivated to try to prevent or reduce the damage to your nerves. There are some treatments such as acupuncture and nutritional supplements that could potentially help. Nutronco has developed PowerOnco, a nutritional supplement to address the many negative side effects from treatment including nerve damage. PowerNerve is a specific nutritional supplement for nerve pain and uses ingredients that have shown good results.